Journal
ANTICANCER RESEARCH
Volume 40, Issue 10, Pages 5445-5456Publisher
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.14555
Keywords
Time-restricted feeding; cancer immunotherapy; highfat diet
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Funding
- University of Alabama at Birmingham Nutrition Obesity Research Center (NORC) Pilot and Feasibility Grant Program
- NCI [T32CA183926, T32CA047888]
- NIH [T32GM008111, R21CA223126]
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Background/Aim: Dietary interventions like timerestricted feeding (TRF) show promising anti-cancer properties. We examined whether therapeutic TRF alone or combined with immunotherapy would diminish renal tumor growth in mice of varying body weights. Materials and Methods: Young (7 week) chow-fed or older (27 week) highfat diet (HFD)-fed BALB/c mice were orthotopically injected with renal tumor cells expressing luciferase. After tumor establishment, mice were randomized to ad libitum feeding or TRF +/- anti-CTLA-4. Body composition, tumor viability and growth, and immune responses were quantified. Results: TRF alone reduced renal tumor bioluminescence in older HFDfed, but not young chow-fed mice. In the latter, TRF mitigated tumor-induced loss of lean- and fat-mass. However, TRF did not alter excised renal tumor weights or intratumoral immune responses and failed to improve anti-CTLA-4 outcomes in any mice. Conclusion: Therapeutic TRF exhibits modest anticancer properties but fails to improve anti-CTLA-4 immune checkpoint blockade in murine renal cancer.
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