Long-term Symptom Control After Laparoscopic Heller Myotomy and Dor Fundoplication for Achalasia

Background. Achalasia is a primary esophageal motility disorder in which there is incomplete relaxation of the lower esophageal sphincter and absence of peristalsis in the lower two thirds of the esophagus. A favored treatment is laparoscopic modified Heller myotomy with Dor fundoplication (LHMDor) with more than 90% immediate beneficial effect. The short-term outcomes of LHMDor are well documented, but stability and durability of postoperative symptom control over time is less understood. Methods. Between 2004 and 2016, 54 patients with achalasia underwent LHMDor (single center). Using validated questionnaires, patients rated their symptoms in five domains: pain, gastroesophageal reflux disease (GERD), dysphagia, regurgitation, and quality of life. Symptom ratings were done preoperatively, 4 weeks postoperatively, 6 months postoperatively, and yearly after the operation. Results. As expected, patients reported marked improvement in dysphagia, odynophagia, regurgitation, GERD, and quality of life after the operation (P < .001). From then on, the symptom control remained durable with respect to absence of pain, regurgitation, and ody-nophagia; however, we observed a recurrence of GERD symptoms beginning 3 to 5 years postoperatively (P = .001 and P = .04, respectively), with associated increased antireflux medication use. After initial LHMDor, 5 pa-tients required endoscopic dilatation an average of 1.5 years postoperatively, and no patient required reopera-tion. Patients reported preserved improved quality of life to 11 years after the operation (P = .001). Conclusions. These results demonstrate the durability of LHMDor in the definitive management of achalasia, offering consistent symptomatic relief and significant improvement in quality of life over the decade after surgery, despite some increase in GERD symptoms and antireflux medication use. (Ann Thorac Surg 2021;111:1717-23) (c) 2021 by The Society of Thoracic Surgeons

Automated summary

The study results demonstrate the durability of LHMDor in the management of achalasia, offering consistent symptomatic relief and significant improvement in quality of life over the decade after surgery. Despite some increase in GERD symptoms and antireflux medication use in some patients in the years following surgery.