Successful treatment of arrhythmia with β-blocker and flecainide combination in pregnant patients with Andersen-Tawil syndrome: A case report and literature review

Andersen-Tawil syndrome (ATS) is a rare disorder characterized by a triad of ventricular arrhythmia (VA), dysmorphic features, and periodic paralysis. Due to the rarity of this condition, less is known about physiologic effect of pregnancy to ATS and arrhythmia. There is no established guideline for peripartum or postpartum treatment and prevention of arrhythmia in ATS; thus, the clinical management is challenging. We reported twoKCNJ2-associated ATS patients who got pregnant and underwent vaginal birth safely. Both individuals had VA, micrognathia without periodic paralysis. beta-blocker plus flecainide could be an effective treatment combination when monotherapy failed to control arrhythmia. VA of two pregnant patients with ATS could be controlled by either physiologic changes associated pregnancy or the combination treatment of beta-blocker and flecainide.

Automated summary

Andersen-Tawil syndrome (ATS) is a rare disorder characterized by ventricular arrhythmia, dysmorphic features, and periodic paralysis. Treatment of arrhythmia during pregnancy in ATS patients is challenging, but a combination of beta-blocker and flecainide may be effective. Two ATS patients successfully underwent vaginal birth, suggesting potential benefits of combined therapy for managing arrhythmia during pregnancy.