Progressive multifocal leukoencephalopathy in multiple myeloma. A literature review and lessons to learn

Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection with high mortality rate usually seen in the context of immunosuppression. Although cases have been reported largely in patients with HIV/AIDS, following the use of monoclonal antibodies and occasionally in haematological malignancies, there is no review to date of patients with smouldering or treated myeloma who developed PML. Here, we conducted a literature search of PML cases in patients with multiple myeloma (MM), analyse patient and disease characteristics and describe the possible mechanisms that could lead to the development of PML. The lack of data and case reports until 2010 may indicate that PML in MM is underdiagnosed. Simultaneously, with an expanding field of new therapeutic options, patients with MM live longer, albeit continually immunosuppressed, and at risk of opportunistic infections. Emerging new treatments for PML in the horizon render the need to look out for this complication mandatory, and more case reports are needed to enrich our knowledge in this field.

Automated summary

PML is a rare opportunistic infection with high mortality rate, often seen in immunosuppressed individuals. While primarily reported in patients with HIV/AIDS, there is a lack of review on PML in smouldering or treated myeloma patients. The underdiagnosis of PML in MM may indicate the need for more case reports to enrich knowledge in this field.