Journal
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
Volume 233, Issue -, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.aanat.2020.151587
Keywords
Nerve regeneration; Animal model; Surgery; American Yorkshire pig
Categories
Funding
- Office of the Assistant Secretary of Defense for Health Affairs, through the Joint Program Committee 8/Clinical and Rehabilitative Medicine Research Program Extremity Regeneration Technology/Therapeutic Development Award [W81XWH-16-2-0067]
Ask authors/readers for more resources
Animal studies are crucial in biomedical research, with large animal models essential for confirming nerve regeneration effects over longer distances required in humans. This paper presents a novel neurovascular injury model in the Sus scrofa domesticus swine, describing the authors' experience and recommendations for creating an effective model.
Animal studies are essential to biomedical research and the cornerstone is a reproducible animal model. While there are many reports on rodent peripheral nerve injury models, a large animal model is essential to confirm the effects of nerve regeneration over the longer distances of regeneration required in humans. Swine have long been used as a large animal model for other surgical and biomedical studies. This paper represents a novel neurovascular injury model in the Sus scrofa domesticus swine (American Yorkshire pig). This paper will describe our experience and recommendations with pre-operative, operative and post-operative protocols and our refinements to produce an effective model. (C) 2020 Elsevier GmbH. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available