Self-Assembly of Photoresponsive Molecular Amphiphiles in Aqueous Media

Amphiphilic molecules, comprising hydrophobic and hydrophilic moieties and the intrinsic propensity to self-assemble in aqueous environment, sustain a fascinating spectrum of structures and functions ranging from biological membranes to ordinary soap. Facing the challenge to design responsive, adaptive, and out-of-equilibrium systems in water, the incorporation of photoresponsive motifs in amphiphilic molecular structures offers ample opportunity to design supramolecular systems that enables functional responses in water in a non-invasive way using light. Here, we discuss the design of photoresponsive molecular amphiphiles, their self-assembled structures in aqueous media and at air-water interfaces, and various approaches to arrive at adaptive and dynamic functions in isotropic and anisotropic systems, including motion at the air-water interface, foam formation, reversible nanoscale assembly, and artificial muscle function. Controlling the delicate interplay of structural design, self-assembling conditions and external stimuli, these responsive amphiphiles open several avenues towards application such as soft adaptive materials, controlled delivery or soft actuators, bridging a gap between artificial and natural dynamic systems.

Automated summary

Amphiphilic molecules with the ability to self-assemble in aqueous environments exhibit a wide range of structures and functions. By incorporating photoresponsive motifs, these molecules can be designed to create non-invasive supramolecular systems that respond to light in water. The delicate balance between structural design, self-assembling conditions, and external stimuli allows for the development of dynamic functions in isotropic and anisotropic systems, leading to applications in soft adaptive materials and controlled delivery systems.