Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 51, Pages 23083-23088Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202010737
Keywords
cross-coupling; nickel; organosilanes; reductive coupling; vinylsilanes
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Funding
- National Natural Science Foundation of China [21772072] Funding Source: Medline
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The cross-electrophile coupling has become a powerful tool for C-C bond formation, but its potential for forging the C-Si bond remains unexplored. Here we report a cross-electrophile Csp(2)-Si coupling reaction of vinyl/aryl electrophiles with vinyl chlorosilanes. This new protocol offers an approach for facile and precise synthesis of organosilanes with high molecular diversity and complexity from readily available materials. The reaction proceeds under mild and non-basic conditions, demonstrating a high step economy, broad substrate scope, wide functionality tolerance, and easy scalability. The synthetic utility of the method is shown by its efficient accessing of silicon bioisosteres, the design of new BCB-monomers, and studies on the Hiyama cross-coupling of vinylsilane products.
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