Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 9, Pages 4434-4447Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202011468
Keywords
biocatalysis; kinetic resolution; oxidative enzymes; total synthesis
Categories
Funding
- EPSRC Centre for Doctoral Training in Synthesis for Biology and Medicine [EP/L015838/1]
- AstraZeneca
- Diamond Light Source
- Defence Science and Technology Laboratory
- Evotec
- GlaxoSmithKline
- Janssen
- Novartis
- Pfizer
- Syngenta
- Takeda
- UCB
- Vertex
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Kinetic resolution using biocatalysis is an excellent complementary technique to traditional asymmetric catalysis, producing valuable oxygenated structures for synthetic route development. Enzymes catalyzing the insertion of an oxygen atom into the substrate, such as the Baeyer-Villiger rearrangement, epoxidation, and hydroxylation, play a key role in oxidative kinetic resolution. These key enantiomer-enriched intermediates have important applications in natural product synthesis.
Kinetic resolution using biocatalysis has proven to be an excellent complementary technique to traditional asymmetric catalysis for the production of enantioenriched compounds. Resolution using oxidative enzymes produces valuable oxygenated structures for use in synthetic route development. This Minireview focuses on enzymes which catalyse the insertion of an oxygen atom into the substrate and, in so doing, can achieve oxidative kinetic resolution. The Baeyer-Villiger rearrangement, epoxidation, and hydroxylation are included, and biological advancements in enzyme development, and applications of these key enantioenriched intermediates in natural product synthesis are discussed.
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