Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 50, Pages 22296-22305Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202003082
Keywords
biological activity; organic chemistry; synthetic methods; toxicity; tox-Profiles
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In this Essay, we present a critical analysis of two common practices in modern chemistry-that is, of using speculations about the greenness and nontoxicity of developed synthesis procedures and of a priori labelling various compounds derived from natural sources as being environmentally safe. We note that every organic molecule that contains functional groups should be biologically active. Thus, analysis of the particular greenness and the potential environmental impact of a given chemical process should account for the biological activity of all its components in a measureable (rather than empirical) way. We highlight the necessity of clarifying discussions on biological activity and toxicity and propose possible ways of introducing tox-Profiles as a reliable overview of the overall toxicity of chemical reactions.
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