Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 3, Pages 1306-1312Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202010870
Keywords
cyclodextrin; gold nanoclusters; NIR-II imaging; protein labelling; tumor imaging
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Funding
- National Natural Science Foundation of China [21635002, 21804134]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT15R11]
- Chinese Government [2017YFE0132300]
- Australian Government [2017YFE0132300]
- Strategic Priority Research Program of the CAS [XDB20000000]
- CAS/SAFEA International Partnership Pro-gram for Creative Research Teams
- Natural Science Foundation of Fujian Province [2019J05157]
- China Postdoctoral Science Foundation [2019M662224]
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The development of bright NIR-II luminescent nanomaterials for efficient protein labelling in vivo without altering their physiological properties is challenging. The synthesized CD-Au NCs can label proteins/antibodies effectively and enable highly efficient in vivo tracking, leading to sensitive tumor-targeted imaging. Additionally, they exhibit good biocompatibility and high renal clearance efficiency in harsh biological environments.
The design of bright NIR-II luminescent nanomaterials that enable efficient labelling of proteins without disturbing their physiological properties in vivo is challenging. We developed an efficient strategy to synthesize bright NIR-II gold nanoclusters (Au NCs) protected by biocompatible cyclodextrin (CD). Leveraging the ultrasmall size of Au NCs (<2 nm) and strong macrocycle-based host-guest chemistry, the as-synthesized CD-Au NCs can readily label proteins/antibodies. Moreover, the labelled proteins/antibodies enable highly efficient in vivo tracking during blood circulation, without disturbing their biodistribution and tumor targeting ability, thus leading to a sensitive tumor-targeted imaging. CD-Au NCs are stable in the harsh biological environment and show good biocompatibility and high renal clearance efficiency. Therefore, the NIR-II biolabels developed in this study provide a promising platform to monitor the physiological behavior of biomolecules in living organisms.
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