Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 52, Pages 23505-23509Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202009553
Keywords
cyclizations; iron; molecular recognition; self-assembly; supramolecular chemistry
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Funding
- National Science Foundation [CHE-1752876, CHE-1708019]
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An endohedrally functionalized self-assembled Fe(4)L(6)cage complex can catalyze oxa-Pictet-Spengler cyclizations of tryptophols and various aldehyde derivatives, showing strong rate accelerations and size-selectivity. Selective molecular recognition of substrates controls the reactivity, and the cage is capable of binding and activating multiple different species along the multistep reaction pathway. The combination of a functionalized active site, size-selective reactivity, and multistep activation, all from a single host molecule, illustrates the biomimetic nature of the catalysis.
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