Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 8, Pages 3967-3973Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202012427
Keywords
aggregation-induced emission; bioimaging; dibodipy; J-aggregation; NIR-II fluorescence
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Funding
- National Key R&D Program of China [2017YFA0207303]
- National Natural Science Foundation of China (NSFC) [21725502, 51961145403, 21904023, 21908030]
- Research Program of Science and Technology Commission of Shanghai Municipality [20JC1411700, 19490713100, 20490710600, 20S31903700]
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An organic dye emitting in the second near-infrared window with enhanced fluorescence intensity was developed for in vivo bioimaging and biosensing applications, enabling high frame rate imaging.
Organic dyes emitting in the second near-infrared (NIR-II, 900-1700 nm) window, with high molar extinction coefficients (MEC) and quantum yields (QY) in aqueous, are essential for in vivo bioimaging and biosensing. In this work, we developed a dibodipy-based aggregation-induced emission (AIE) fluorescent probe, THPP, to meet this aim. THPP exhibits a high MEC and has intensified absorption and emission in J-aggregated state, which significantly enhance the fluorescence intensity (approximate to 55 folds) and extend the maximal absorption/emission wavelengths to 970/1010 nm in NIR-II region. Based on the bright THPP, imaging with a high frame rate (34 frames per second) at a deep valid penetration depth up to 6 mm can be achieved. This enabled simultaneous and dynamic imaging of vasculatures and deep tissues. Besides, we succeeded in monitoring the respiratory rate of acute-lung-injury mice and tracing the collateral circulation process with a high frame rate.
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