Journal
ANALYTICAL CHEMISTRY
Volume 92, Issue 20, Pages 13734-13741Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.0c01597
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Funding
- Academy of Finland [275089, 2515752, 276627, 1321472]
- Academy of Finland (AKA) [275089, 276627, 275089, 276627] Funding Source: Academy of Finland (AKA)
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In this study, we applied a new IR laser-beamfocusing technique to enable sub-100 mu m spatial resolution in laser ablation atmospheric pressure photoionization (LAAPPI) and laser ablation electrospray ionization (LAESI) mass spectrometry imaging (MSI). After optimization of operational parameters, both LAAPPI- and LAESI-MSI with a spatial resolution of 70 mu m produced high-quality MS images, which allowed accurate localization of metabolites and lipids in the mouse and rat brain. Negative and positive ion LAAPPI- and LAESI-MS detected many of the same metabolites and lipids in the brain. Many compounds were also detected either by LAAPPI- or LAESI-MS, indicating that LAAPPI and LAESI are more complementary than alternative methods.
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