Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 412, Issue 29, Pages 8167-8176Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-020-02951-8
Keywords
Manganese dioxide nanosheets; Fluorescent polymer dots; Fluorescence resonance energy transfer; Nanoplatform
Funding
- National Natural Science Foundation of China [21605021]
- China Postdoctoral Science Foundation [2019M652241]
- Young and Middle-Aged Talent Training Project of Fujian Provincial Health and Family Planning Commission [2018-ZQN-75]
- Medical Innovation grant of Fujian Province [2018-CX-49]
- Startup Fund of Mengchao Hepatobiliary Hospital of Fujian Medical University [QDZJ-2017-004]
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Fluorescence biosensors that enable highly sensitive detection of glutathione (GSH) are in great demand for various biological investigations and early disease diagnoses. Here, we report a turn-on fluorescence nanoplatform based on fluorescent semiconducting polymer nanoparticle@MnO2 nanosheets (P-dot@MnO2) nanocomposites for rapid homogeneous determination of GSH. The near-infrared (NIR) fluorescent P-dots were prepared by doping NIR dyes into polymer matrix and then encompassed by MnO2, which resulted in a remarkable fluorescence quenching. Owing to the selective decomposition of MnO(2)by GSH, the fluorescence recovery was achieved in the presence of GSH. On the basis of the target-induced turn-on fluorescence response, the developed nanoplatform can readily detect GSH with a high sensitivity up to 0.26 mu M, as well as a superior specificity. Furthermore, it was successfully applied in monitoring the intracellular GSH in living cells, revealing its great potential in biomedical applications.
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