Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 85, Issue 3, Pages -Publisher
WILEY
DOI: 10.1111/aji.13357
Keywords
chronic endometritis; implantation failure; infertility; pregnancy outcomes
Categories
Funding
- Japan Society for the Promotion of Science [16K11083, 19K09752]
- Grants-in-Aid for Scientific Research [16K11083, 19K09752] Funding Source: KAKEN
Ask authors/readers for more resources
The study found that in cases of CE, the rate of miscarriage during pregnancy increased, while the rate of term birth significantly decreased. CE had an impact on variables such as miscarriage, term birth, and live birth.
Problem Chronic endometritis (CE) influences the clinical outcomes of assisted reproductive technology. However, the effect of CE on the pregnancy outcome is still unknown. Method of study A retrospective case-control study was conducted in a single university. Subjects who conceived by in vitro fertilization within a year after a histological diagnosis of CE under 40 years of age from September 2013 to December 2017 were extracted. The rates of miscarriage, preterm birth, term birth, and live birth per pregnancy according to the presence or absence of CE were analyzed. A logistic regression analysis was performed for miscarriage, preterm birth, term birth, and live birth for eight explanatory variables of seven infertility factors and CE. Results A total of 39 pregnancies in 38 subjects with non-CE and 35 pregnancies in 32 subjects with CE were ultimately analyzed. The rates of miscarriage, preterm birth, term birth, and live birth per pregnancy were 12.8% and 40.0% (P < .03), 2.6% and 14.3% (P = .1), 84.6% and 45.7% (P < .001) and 84.6% and 57.1% (P < .03) in the Non-CE and CE groups, respectively, although only the analysis for tem birth rate had sufficient power to exclude Type II error. In logistic analysis, CE was a factor affecting the objective variables of miscarriage, term birth, and live birth. Conclusions The term birth rate among pregnancies decreased mainly due to an increase in miscarriages when CE was detected before pregnancy in patients treated with in vitro fertilization. A histopathological diagnosis of CE adversely affected the term birth rate per pregnancy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available