Journal
AMERICAN JOURNAL OF PATHOLOGY
Volume 191, Issue 1, Pages 131-143Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajpath.2020.09.011
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Funding
- NIH [HL-132919, GM118355-03S]
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Sialidases play a promoting role in adipose tissue and liver inflammation induced by high-fat diet. Inhibiting sialidases can alleviate steatosis and inflammation.
High-fat diet (HFD)-induced inflammation and steatosis of adipose tissue and liver are associated with a variety of serious health risks. Sialic acids are found as the distal terminal sugar on glycoproteins, which are removed by sialidases (neuraminidases). In humans and mice, pulmonary fibrosis is associated with up-regulation of sialidases, and injections of sialidase inhibitors attenuate bleomycin-induced pulmonary fibrosis. Sialidase levels are altered in obese rodents and humans. This report shows that for mice on an HFD, injections of the sialidase inhibitor N-acetyl-2,3-dehydro-2-deoxyneuraminic acid inhibit weight gain, reduce steatosis, and decrease adipose tissue and liver inflammation. Compared with control, mice lacking the sialidase neuraminidase 3 have reduced HFD-induced adipose tissue and liver inflammation. These data suggest that sialidases promote adipose and liver inflammation in response to a high-fat diet.
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