Journal
AMERICAN JOURNAL OF HYPERTENSION
Volume 34, Issue 3, Pages 278-281Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ajh/hpaa169
Keywords
ACE2; aldosterone; angiotensin II; blood pressure; COVID-19; hypertension; SARS-CoV-2
Categories
Funding
- German Center for Infection Research
- Federal Ministry of Education and Research, Germany [8039801926]
- Berta-Ottenstein-Programme for Advanced Clinician Scientists, Faculty of Medicine, University of Freiburg
- IMM-PACT-Programme for Clinician Scientists, Faculty of Medicine, University of Freiburg
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [413517907]
- Margarete von Wrangell fellowship, Ministry of Science, Research and the Arts (MWK) of the state of Baden-Wuerttemberg
- German Research Foundation [CRC1425]
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In this study, researchers did not find significant differences in serum levels of ACE2, angiotensin II, aldosterone, RAAS activity surrogate parameters such as serum potassium, and blood pressure between COVID-19 patients and the control group.
Background The role of the renin-angiotensin-aldosterone system (RAAS) in coronavirus disease 2019 (COVID-19) is controversially discussed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells by binding to angiotensin-converting enzyme 2 (ACE2) and activity of the RAAS may affect susceptibility to SARS-CoV-2 infection and outcome of patients with COVID-19. Methods In this prospective single-center study, we determined the serum levels of ACE2, angiotensin II, and aldosterone in patients with COVID-19 compared with control patients presenting with similar symptoms in the emergency unit. Results We analyzed serum samples from 24 SARS-CoV-2 positive and 61 SARS-CoV-2 negative patients. SARS-CoV-2 positive and control patients did not differ in baseline patients characteristics, symptoms, and clinical presentation. Mean serum concentrations of ACE2, angiotensin II, and aldosterone did not differ between the SARS-CoV-2 positive and the control group. In line with this, serum potassium as surrogate parameter for RAAS activity and blood pressure were similar in both groups. Conclusions In summary, we did not find evidence for altered RAAS activity including angiotensin II, aldosterone, or potassium levels, and blood pressure in patients with COVID-19.
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