Journal
AMERICAN JOURNAL OF GASTROENTEROLOGY
Volume 115, Issue 12, Pages 2098-2102Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.14309/ajg.0000000000000957
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Funding
- NIH [R01DK101856]
- NCI [2-P30-CA016086-40]
- NIEHS [2-P30ES010126-15A1]
- UCRF
- NCBT [2015-IDG-1007]
- Swiss National Science Foundation [32473B_185008]
- UNC Center for GI Biology and Disease (NIH) [P30 DK034987]
- Swiss National Science Foundation (SNF) [32473B_185008] Funding Source: Swiss National Science Foundation (SNF)
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INTRODUCTION: We investigated whether dilation modifies the association between symptoms and esophageal eosinophilia (peak esophageal eosinophils/high-power field [eos/hpf]) in patients with eosinophilic esophagitis enrolled into a randomized trial comparing the efficacy of budesonide and fluticasone. METHODS: Baseline Dysphagia Symptom Questionnaire and Eosinophilic Esophagitis Activity Index were available in 102 and 73 patients, respectively, of whom 56 and 39 underwent dilation at screening endoscopy before symptom assessment. The pair-wise relationship between Dysphagia Symptom Questionnaire, Eosinophilic Esophagitis Activity Index, and eos/hpf was analyzed with nonparametric correlations. RESULTS: In nondilated patients, the association between baseline eos/hpf and symptoms was moderate and significant, although it was abolished in dilated patients. DISCUSSION: Dilation modifies association between symptoms and eos/hpf ( NCT02019758).
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