Journal
ALZHEIMERS & DEMENTIA
Volume 17, Issue 1, Pages 70-80Publisher
WILEY
DOI: 10.1002/alz.12176
Keywords
cognitive aging; cognitive reserve; education; racial/ethnic differences
Categories
Funding
- National Institute on Aging
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The study suggests that educational attainment has a positive impact on cognitive reserve for Whites, attenuating the negative effects of certain brain integrity indicators on memory and language abilities. However, this impact is not significant for Blacks and Hispanics.
IntroductionWe examined whether educational attainment differentially contributes to cognitive reserve (CR) across race/ethnicity. Methods: A total of 1553 non-Hispanic Whites (Whites), non-Hispanic Blacks (Blacks), and Hispanics in the Washington Heights-Inwood Columbia Aging Project (WHICAP) completed structural magnetic resonance imaging. Mixture growth curve modeling was used to examine whether the effect of brain integrity indicators (hippocampal volume, cortical thickness, and white matter hyperintensity [WMH] volumes) on memory and language trajectories was modified by education across racial/ethnic groups. Results: Higher educational attainment attenuated the negative impact of WMH burden on memory (beta = -0.03; 99% CI: -0.071, -0.002) and language decline (beta = -0.024; 99% CI:- 0.044, -0.004), as well as the impact of cortical thinning on level of language performance for Whites, but not for Blacks or Hispanics. Discussion: Educational attainment does not contribute to CR similarly across racial/ethnic groups.
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