Journal
ADVANCES IN CHRONIC KIDNEY DISEASE
Volume 27, Issue 5, Pages 365-376Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ackd.2020.09.003
Keywords
AKI; COVID-19; Collapsing GN; Pathology; Kidney failure
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Funding
- National Institutes of Health (NIH) [K23 DK 117014]
- Claflin Distinguished Scholars Award
- Raggio Family
- Hall Family
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Acute kidney injury (AKI) is common among hospitalized patients with Coronavirus Infectious Disease 2019 (COVID-19), with the occurrence of AKI ranging from 0.5% to 80%. The variability in the occurrence of AKI has been attributed to the difference in geographic locations, race/ethnicity, and severity of illness. AKI among hospitalized patients is associated with increased length of stay and in-hospital deaths. Even patients with AKI who survive to hospital discharge are at risk of developing chronic kidney disease or end-stage kidney disease. An improved knowledge of the pathophysiology of AKI in COVID-19 is crucial to mitigate and manage AKI and to improve the survival of patients who developed AKI during COVID-19. The goal of this article is to provide our current understanding of the etiology and the pathophysiology of AKI in the setting of COVID-19. (C) 2020 by the National Kidney Foundation, Inc. All rights reserved.
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