Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 362, Issue 22, Pages 4861-4875Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202000808
Keywords
Benzazepine; Benzodiazepine; C-H activation; Oxidative annulation; Transition-metal catalyst
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Funding
- MINECO [CTQ2017-87939R]
- MINECO (ORFEO-CINQA network) [RED2018-102387-T]
- Xunta de Galicia [ED431 C 2018/04, ED481 A-2018/34]
- Xunta de Galicia (Centro singular de investigacion de Galicia accreditation 2019-2022) [ED431G 2019/03]
- European Union (European Regional Development Fund - ERDF)
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Benzazepines and benzodiazepines, benzofused seven-membered N-heterocycles, compose an important family of natural products and pharmaceuticals. Although certainly important and effectives, classical synthetic methods of these cyclic compounds involve methodologies that often require multistep procedures, with generation of waste materials and lack of sustainability. By contrast, cycloadditions based on transition metal catalyzed C-H bond activations (oxidative annulations) have emerged as appealing strategies for more sustainable synthetic processes. In this review, we focus our attention to describe the state-of-the-art transition-metal-catalyzed annulationsviaC-H activations to benzazepines and benzodiazepines.
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