Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 362, Issue 23, Pages 5363-5367Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202000985
Keywords
aryl halides; nickel; reductive coupling; radical reactions; C-C coupling
Categories
Funding
- National Science Foundation of China [21971228, 21772187]
- China Postdoctoral Science Foundation [2019 M653580]
Ask authors/readers for more resources
A nickel-catalyzed direct trifluoroethylation of aryl iodides with an industrial raw material CF3CH2I has been developed, demonstrating high efficiency, excellent functional-group compatibility, especially with large sterically hindered groups. The key to success is the combination of nickel with readily available nitrogen and phosphine ligands. The powerful potential of this strategy is further demonstrated by the late-stage modification of several derived bioactive molecules.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available