Journal
ADVANCED MATERIALS
Volume 32, Issue 42, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202002439
Keywords
catalase-mimics; glutathione depletion; nanozymes; peroxidase-mimics; tumor nanocatalytic therapy
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Funding
- National Natural Science Foundation of China [NSFC 51972075, 51772059, 51929201, 51720105015, 51602072]
- Natural Science Foundation of Heilongjiang Province [YQ2019E014]
- Postdoctoral Scientific Research Developmental Fund [LBH-Q18034]
- Science and Technology Cooperation Project between Chinese Government [2017YFE0132300]
- Science and Technology Cooperation Project between Australian Government [2017YFE0132300]
- Fundamental Research funds for the Central Universities
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Nanocatalytic therapy, using artificial nanoscale enzyme mimics (nanozymes), is an emerging technology for therapeutic treatment of various malignant tumors. However, the relatively deficient catalytic activity of nanozymes in the tumor microenvironment (TME) restrains their biomedical applications. Here, a versatile and bacteria-like PEG/Ce-Bi@DMSN nanozyme is developed by coating uniform Bi(2)S(3)nanorods (NRs) with dendritic mesoporous silica (Bi2S3@DMSN) and then decorating ultrasmall ceria nanozymes into the large mesopores of Bi2S3@DMSN. The nanozymes exhibit dual enzyme-mimic catalytic activities (peroxidase-mimic and catalase-mimic) under acidic conditions that can regulate the TME, that is, simultaneously elevate oxidative stress and relieve hypoxia. In addition, the nanozymes can effectively consume the overexpressed glutathione (GSH) through redox reaction. Photothermal therapy (PTT) is introduced to synergistically improve the dual enzyme-mimicking catalytic activities and depletion of the overexpressed GSH in the tumors by photonic hyperthermia. This is achieved by taking advantage of the desirable light absorbance in the second near-infrared (NIR-II) window of the PEG/Ce-Bi@DMSN nanozymes. Subsequently the reactive oxygen species (ROS)-mediated therapeutic efficiency is significantly improved. Therefore, this study provides a proof of concept of hyperthermia-augmented multi-enzymatic activities of nanozymes for tumor ablation.
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