Journal
ADVANCED MATERIALS
Volume 32, Issue 48, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202004481
Keywords
immunotherapy; nanoporphyrin; photodynamic therapy; photothermal therapy; single laser
Categories
Funding
- National Key Research and Development Program of China [2018YFA0704003, 2017YFA0205700, 2017YFE0100200]
- Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project [2018B030308003]
- Basic Research Program of Shenzhen [JCYJ20170412111100742, JCYJ20180305163452667, JCYJ20180507182413022]
- Shenzen Science and Technology Program [KQTD20190929172538530]
- National Natural Science Foundation of China [21874119, 81972900, 81903564]
- Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China [161032]
- Natural Science Foundation of Shaanxi Province [2019JZ-13]
- Fundamental Research Funds for the Central University [GK201802002, 2020CBLZ009]
Ask authors/readers for more resources
Simultaneous photodynamic therapy (PDT) and photothermal therapy (PTT) can reduce the risks of drug leakage, body burden, and preparation complexity in traditional combination PDT/PTT. Here, a versatile nanoporphyrin (Pp18-lipos) self-assembled from lipid-purpurin 18 conjugates (Pp18-lipids) and pure lipids is presented. The as-prepared Pp18-lipos with 2 mol% Pp18-lipids can perform effective PDT and fluorescence imaging. The Pp18-lipos with 65 mol% Pp18 can perform potent PTT and photoacoustic imaging. The chelation of Mn(2+)endows the Pp18-lipids-Mn(2+)a highT(1)-weighted magnetic resonance imaging contrast. Notably, pretreatment of low-dose PDT facilitates the endocytosis and tumor accumulation of Pp18-lipos, thus achieving synergistic PDT/PTT. Upon exposure to a single 705 nm-laser, the combination of PDT/PTT achieves a significantly higher tumor growth inhibition rate than PDT or PTT alone. In addition, it is found that the synergistic PDT/PTT triggers more potent anti-tumor immune response including tumor infiltration of immune cells and release of related cytokines.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available