Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 31, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202006839
Keywords
colloidal crystals; microfluidic; microneedles; wearable sensors; wound healing
Categories
Funding
- National Key R&D Program of China [2019YFA09005200]
- National Natural Science Foundation of China [81673321]
- Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture [XTC1812]
- special funds for the introduction of talents of Nanjing Tech University [39828122]
- Natural Science Foundation of Jiangsu Province
- Natural Science Research of Jiangsu Higher Education Institutions of China
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The i-SMD is an intelligent dressing with drug release and biochemical analysis capabilities, showing promise in facilitating wound healing.
Wounds, especially those caused by chronic diseases, are severe threats to human health. To facilitate their recovery, considerable efforts have been devoted to the generation of wound tissues and the detection of wound biomarkers. Here, an intelligent origami silk fibroin microneedle-structured dressing (i-SMD) with a smart drug release system, biochemical sensing, and physiological monitoring ability for epidermal sensing and wound healing, is presented. By utilizing temperature-responsiveN-isopropylacrylamide (NIPAM) hydrogel and inverse opal (IO) photonic crystals (PCs) as a smart drug release system, controllable drug release is achieved on the i-SMD. The patterned microfluidic channels on the i-SMD and IO PCs enable the liquid to flow spontaneously in the channels, thereby achieving sensitive multiple biochemical analysis of inflammatory factors; meanwhile, microelectronic circuits integrated on the i-SMD enable sensitive motion monitoring. Notably, the performance of i-SMD in facilitating wound healing is demonstrated by treating full-thickness cutaneous wounds in a diabetic mouse model, indicating the remarkable prospects of i-SMD in wound management and other related biomedical fields.
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