Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 30, Issue 49, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202002234
Keywords
antioxidant therapies; endotoxemia; endotoxemia treatments; enzyme-mimicking; oxidative stress prevention
Categories
Funding
- National Natural Science Foundation of China [51903168, 51673125, 51873115]
- China Postdoctoral Science Foundation [2018M643485]
- International Visiting Program for Excellent Young Scholars of SCU
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Oxidative stress occurs when excess oxidative free radicals are produced in cells, which can overwhelm the normal antioxidant capacity and play an important role in many disease states. Thus, advanced functional materials which can mimic the intracellular antioxidant defense system have a huge potential to become candidates for curing oxidative stress triggered diseases. Herein, a high-performance nanoplatform is developed with a green and mild strategy by combining mimic-enzymatic antioxidant (Fe3O4) and nonenzymatic antioxidant (tannic acid (TA)) for constructing antioxidant defense system (Fe3O4 @ TAn nanoflowers (NFs)). Owing to the excellent peroxidase (POD)-mimic and catalase (CAT)-mimic capacities of Fe(3)O(4)in various conditions, the antioxidant ability of TA and the flower-like morphology, the Fe3O4 @ TAn NFs can effectively scavenge multiple reactive oxygen and nitrogen species. In vitro experiments verify that the Fe3O4 @ TAn NFs demonstrate synergetic antioxidative properties, which can be used to protect blood and cellular components against oxidative damage. Meanwhile, in vivo experiments demonstrate that the Fe3O4 @ TAn NFs exhibit excellent therapeutic effects for systemic inflammation on endotoxemia mice and promote wound healing owing to the excellent antioxidant and anti-inflammatory properties. Thus, this antioxidant defense system expands the toolbox of antioxidative materials and shows potential applications in oxidative stress treatment.
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