Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 156, Issue -, Pages 133-187Publisher
ELSEVIER
DOI: 10.1016/j.addr.2020.08.008
Keywords
Drug delivery; Polypeptides; Recombinant proteins; Bioinspired materials; Hierarchical self-assembly
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Funding
- NSF
- National Institutes of Health (NIH) through an MIRA [R35GM127042, R21CA237705]
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Engineering protein and peptide-based materials for drug delivery applications has gained momentum due to their biochemical and biophysical properties over synthetic materials, including biocompatibility, ease of synthesis and purification, tunability, scalability, and lack of toxicity. These biomolecules have been used to develop a host of drug delivery platforms, such as peptide- and protein-drug conjugates, injectable particles, and drug depots to deliver small molecule drugs, therapeutic proteins, and nucleic acids. In this review, we discuss progress in engineering the architecture and biological functions of peptide-based biomaterials-naturally derived, chemically synthesized and recombinant- with a focus on the molecular features that modulate their structure function relationships for drug delivery. (C) 2020 Published by Elsevier B.V.
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