Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 159, Issue -, Pages 94-119Publisher
ELSEVIER
DOI: 10.1016/j.addr.2020.10.006
Keywords
High-density lipoproteins; Inflammation; Metabolic diseases; Infectious diseases; Auto-immune diseases; Neurological diseases; Chronic kidney disease
Categories
Funding
- Interdisciplinary Center for Clinical Researchwithin the faculty ofMedicine at the RWTH Aachen University
- DZHK (German Centre for Cardiovascular Research)
- BMBF (German Ministry of Education and Research)
- NWOZonMw Veni [91619053]
- DFG [SFB/TRR219-TPC09, SFB/TRR219-TP-S03]
Ask authors/readers for more resources
High-density lipoprotein (HDL) plays an important role in lipid metabolism and especially contributes to the reverse cholesterol transport pathway. Over recent years it has become clear that the effect of HDL on immune modulation is not only dependent on HDL concentration but also and perhaps even more so on HDL function. This review will provide a concise general introduction to HDL followed by an overview of post-translational modifications of HDL and a detailed overview of the role of HDL in inflammatory diseases. The clinical potential of HDL and its main apolipoprotein constituent, apoA-I, is also addressed in this context. Finally, some conclusions and remarks that are important for future HDL-based research and further development of HDL-focused therapies are discussed. (C) 2020 The Author(s). Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available