Journal
ACTA PAEDIATRICA
Volume 110, Issue 3, Pages 833-837Publisher
WILEY
DOI: 10.1111/apa.15585
Keywords
closed loop automated oxygen delivery; desaturation; hyperoxia
Categories
Funding
- National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London
- MRC [MC_PC_14105] Funding Source: UKRI
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The study showed that using a closed loop automated oxygen control system can reduce the duration and severity of desaturation episodes in preterm, ventilated infants, increase the time spent in the targeted oxygen range, and decrease the number of manual adjustments made to the inspired oxygen concentration.
Aim: To determine whether closed loop automated oxygen control resulted in a reduction in the duration and severity of desaturation episodes and the number of blood gases and chest radiographs in preterm, ventilated infants. Methods: Infants were studied on two consecutive days for 12 hours on each day. They were randomised to receive standard care (standard period) or standard care with a closed loop automated oxygen control system (automated oxygen control period) first. Results: Twenty-four infants with a median gestational age of 25.7 (range 23.1-32.6) weeks were studied at a median postconceptional age of 27.4 (range 24.3-34.9) weeks. During the automated oxygen control period, there were fewer desaturations that lasted >30 seconds (P = .032) or >60 seconds (P = .002), infants spent a higher proportion of the time within their target SpO(2) range during the automated oxygen control period (P < .001), and fewer manual adjustments were made to the inspired oxygen concentration (mean 0.58 vs mean 11.29) (P < .001). There were no significant differences in the number of blood gases (P = .872) or chest radiographs (P = .366) between the two periods. Conclusion: Closed loop automated oxygen delivery resulted in fewer prolonged desaturations with more time spent in the targeted oxygen range.
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