Related references
Note: Only part of the references are listed.C99 selectively accumulates in vulnerable neurons in Alzheimer's disease
Maria Pulina et al.
ALZHEIMERS & DEMENTIA (2020)
PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis
Chiara Fedeli et al.
AUTOPHAGY (2019)
Does Intraneuronal Accumulation of Carboxyl-terminal Fragments of the Amyloid Precursor Protein Trigger Early Neurotoxicity in Alzheimer's Disease?
L. Lauritzen et al.
CURRENT ALZHEIMER RESEARCH (2019)
Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)
Ying Jiang et al.
JOURNAL OF NEUROSCIENCE (2019)
Mitochondria' dynamics and transport in Alzheimer's disease
Padraig J. Flannery et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2019)
Powerhouse of the mind: mitochondria! plasticity at the synapse
Meghan J. Rossi et al.
CURRENT OPINION IN NEUROBIOLOGY (2019)
Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria
Nadia Cummins et al.
EMBO JOURNAL (2019)
A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ (vol 104, pg 256, 2019)
Dylan Kwart et al.
NEURON (2019)
Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models
Inger Lauritzen et al.
TRANSLATIONAL NEURODEGENERATION (2019)
beta-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models
Thomas Goiran et al.
BIOLOGICAL PSYCHIATRY (2018)
Anti-Amyloid-β Monoclonal Antibodies for Alzheimer's Disease: Pitfalls and Promise
Christopher H. van Dyck
BIOLOGICAL PSYCHIATRY (2018)
Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation
Thomas Goiran et al.
CELL DEATH AND DIFFERENTIATION (2018)
Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance
Sarah Pickles et al.
CURRENT BIOLOGY (2018)
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease
P. Hemachandra Reddy et al.
HUMAN MOLECULAR GENETICS (2018)
Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease
Maria Manczak et al.
HUMAN MOLECULAR GENETICS (2018)
Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3 x TgAD and 2 x TgAD mice
Alexandre Bourgeois et al.
NEUROBIOLOGY OF AGING (2018)
The interactions of p53 with tau and Aβ as potential therapeutic targets for Alzheimer's disease
Maja Jazvinscak Jembrek et al.
PROGRESS IN NEUROBIOLOGY (2018)
Alzheimer's Transgenic Model Is Characterized by Very Early Brain Network Alterations and β-CTF Fragment Accumulation: Reversal by β-Secretase Inhibition
Siddhartha Mondragon-Rodriguez et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2018)
Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer's Disease
Tim L. Emmerzaal et al.
JOURNAL OF ALZHEIMERS DISEASE (2018)
Are N- and C-terminally truncated A species key pathological triggers in Alzheimer's disease?
Julie Dunys et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease
Christy O. Y. Hung et al.
CELL REPORTS (2018)
Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes
Dolores Del Prete et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein
G. Kaur et al.
MOLECULAR PSYCHIATRY (2017)
Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway
Alexis E. Gonzalez et al.
FASEB JOURNAL (2017)
Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor
Renaud Bussiere et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
Vincenzo Sorrentino et al.
NATURE (2017)
Mitophagy in neurodegeneration and aging
Elayne M. Fivenson et al.
NEUROCHEMISTRY INTERNATIONAL (2017)
Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer's disease
Lin-Lin Xu et al.
NEUROREPORT (2017)
NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models
Chuanbin Yang et al.
AUTOPHAGY (2017)
Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease
Marta Pera et al.
EMBO JOURNAL (2017)
Amyloid precursor protein processing and bioenergetics
Heather M. Wilkins et al.
BRAIN RESEARCH BULLETIN (2017)
PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease
Patricia Martin-Maestro et al.
HUMAN MOLECULAR GENETICS (2016)
Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology
Inger Lauritzen et al.
ACTA NEUROPATHOLOGICA (2016)
The Cellular Phase of Alzheimer's Disease
Bart De Strooper et al.
CELL (2016)
Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin
Yu Hu et al.
ONCOTARGET (2016)
Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology
Yajie Wang et al.
SCIENTIFIC REPORTS (2016)
Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1
Rebecca Rojansky et al.
ELIFE (2016)
Autophagic and lysosomal defects in human tauopathies: analysis of postmortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy
Antonio Piras et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)
Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease
Liang Zhang et al.
SCIENTIFIC REPORTS (2016)
Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains
Xuan Ye et al.
HUMAN MOLECULAR GENETICS (2015)
The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes
Hoang S. Nhan et al.
ACTA NEUROPATHOLOGICA (2015)
Amyloid-beta Peptides are Generated in Mitochondria-Associated Endoplasmic Reticulum Membranes
Bernadette Schreiner et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Oxidative stress and mitochondrial dysfunction in Alzheimer's disease
Xinglong Wang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease
Marta Pera et al.
ACTA NEUROPATHOLOGICA (2013)
Loss of iron triggers PINK1/Parkin-independent mitophagy
George F. G. Allen et al.
EMBO REPORTS (2013)
Diminished Parkin Solubility and Co-Localization with Intraneuronal Amyloid-beta are Associated with Autophagic Defects in Alzheimer's Disease
Irina Lonskaya et al.
JOURNAL OF ALZHEIMERS DISEASE (2013)
Mitochondrial respiratory chain Complexes I and IV are impaired by β-amyloid via direct interaction and through Complex I-dependent ROS production, respectively
A. Bobba et al.
MITOCHONDRION (2013)
Cellular and molecular mechanisms of mitochondrial function
Laura D. Osellame et al.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2012)
Upregulated function of mitochondria-associated ER membranes in Alzheimer disease
Estela Area-Gomez et al.
EMBO JOURNAL (2012)
Evidence that the Amyloid-β Protein Precursor Intracellular Domain, AICD, Derives From β-Secretase-Generated C-Terminal Fragment
Brice Flammang et al.
JOURNAL OF ALZHEIMERS DISEASE (2012)
Ryanodine Receptor Blockade Reduces Amyloid-β Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease
Benedicte Oules et al.
JOURNAL OF NEUROSCIENCE (2012)
Differential Effects between γ-Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice
Yasuyuki Mitani et al.
JOURNAL OF NEUROSCIENCE (2012)
The β-Secretase-Derived C-Terminal Fragment of βAPP, C99, But Not Aβ, Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus
Inger Lauritzen et al.
JOURNAL OF NEUROSCIENCE (2012)
Physiological Roles of Mitochondrial Reactive Oxygen Species
Laura A. Sena et al.
MOLECULAR CELL (2012)
From Mitochondrial Dysfunction to Amyloid Beta Formation: Novel Insights into the Pathogenesis of Alzheimer's Disease
Kristina Leuner et al.
MOLECULAR NEUROBIOLOGY (2012)
Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia
Robert Tamayev et al.
MOLECULAR NEURODEGENERATION (2012)
Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice
Latha Devi et al.
NEUROBIOLOGY OF DISEASE (2012)
Mitochondrial gamma-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein
Pavel F. Pavlov et al.
FASEB JOURNAL (2011)
An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model
Masashi Asai et al.
FASEB JOURNAL (2011)
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage
Maria Manczak et al.
HUMAN MOLECULAR GENETICS (2011)
Behavioural phenotype of APPC100.V717F transgenic mice over-expressing a mutant Aβ-bearing fragment is associated with reduced NMDA receptor density
Wah Chin Boon et al.
BEHAVIOURAL BRAIN RESEARCH (2010)
Role of Mitochondrial Amyloid-beta in Alzheimer's Disease
John Xi Chen et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Formic acid is essential for immunohistochemical detection of aggregated intraneuronal Aβ peptides in mouse models of Alzheimer's disease
Ditte Z. Christensen et al.
BRAIN RESEARCH (2009)
Parkin promotes intracellular Aβ1-42 clearance
Mark P. Burns et al.
HUMAN MOLECULAR GENETICS (2009)
γ-Secretase Inhibition Reduces Spine Density In Vivo via an Amyloid Precursor Protein-Dependent Pathway
Tobias Bittner et al.
JOURNAL OF NEUROSCIENCE (2009)
Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice
S. Hauptmann et al.
NEUROBIOLOGY OF AGING (2009)
Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
Xinglong Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease
P. Hemachandra Reddy et al.
TRENDS IN MOLECULAR MEDICINE (2008)
Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease
Hindupur K. Anandatheerthavarada et al.
NEUROSCIENTIST (2007)
A guided tour into subcellular colocalization analysis in light microscopy
S. Bolte et al.
JOURNAL OF MICROSCOPY (2006)
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes
Kristine M. Robinson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Distribution and dynamics of Lamp1-containing endocytic organelles in fibroblasts deficient in BLOC-3
JM Falcón-Pérez et al.
JOURNAL OF CELL SCIENCE (2005)
ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease
JW Lustbader et al.
SCIENCE (2004)
Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets
G Evin et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2003)
Triple-transgenic model of Alzheimer's disease with plaques and tangles:: Intracellular Aβ and synaptic dysfunction
S Oddo et al.
NEURON (2003)
Effects of the carboxyl-terminal fragment of Alzheimer's amyloid precursor protein and amyloid β-peptide on the production of cytokines and nitric oxide in glial cells
JC Rah et al.
FASEB JOURNAL (2001)
Wild-type but not Parkinson's disease-related Ala-53 → Thr mutant α-synuclein protects neuronal cells from apoptotic stimuli
CA da Costa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Share Paper
