Journal
ACTA BIOMATERIALIA
Volume 115, Issue -, Pages 136-147Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2020.08.023
Keywords
Microneedle; Poly(ionic liquid); Acne infection; Active pharmaceutical ingredient; Bacteria killing
Funding
- Natural Science Foundation of China [U1862109, 51973041, 81772115, 81571930]
- Shanghai Natural Science Foundation [19ZR1408800]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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As an inflammatory skin disease of pilosebaceous follicles, Propionibacterium acnes (P. acnes) can aggravate local inflammatory responses and forms acne lesions. However, due to the skin barrier, various transdermal measures other than antibiotic creams are necessary. Microneedle (MN) patches are emerging platforms for the transdermal delivery of various therapeutics since it can effectively create transport pathways in the epidermis. Herein, we develop an active pharmaceutical ingredient poly(ionic liquid) (API PIL)-based MN patches containing salicylic acid (SA). The PIL-based MNs are simply prepared through photo-crosslinking of an imidazolium-type ionic liquid (IL) monomer in MN micro-molds, and following by anion exchange with salicylic acid anions (SA-). The fabricated SA-loaded PIL-MNs exhibited therapeutic efficiency in the topical treatment of P. acnes infection in vitro and in vivo. These active pharmaceutical ingredient PIL-based MNs can improve acne treatment, demonstrating potential applications for skin diseases. Statement of Significance Microneedle (MN) patches can be used as platforms for transdermal delivery of various therapeutics to treat bacterial infection. Here, a facile strategy was developed to synthesize active pharmaceutical ingredient poly(ionic liquid)-based microneedle patches by anion-exchange with salicylic acid anion (SA-). The fabricated SA-loaded PIL-MNs are active on not only anti-bacteria but also anti-inflammation in P. acnes treated mice, and may have potential applications for skin acne infection. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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