Journal
ACS NANO
Volume 14, Issue 10, Pages 12854-12865Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c03629
Keywords
nitric oxide; gold nanorod; nanoplatform; catalysis; nitric oxide synthase; arginine; cardiovascular disease
Categories
Funding
- Strategic Priority Research Program of Chinese Academy of Sciences [XDB36000000]
- National Basic Research Program of China [2016YFA0200903, 2016YFA0203200, 2016YFA0201600]
- National Natural Science Foundation of China [31971322]
- Science Fund for Creative Research Groups of the National Natural Science Foundation of China [11621505]
- CAS Key Research Program for Frontier Sciences [QYZDJ-SSW-SLH022]
- Users with Excellence Project of Hefei Science Center CAS [2018HSC-UE004]
- Research and Development Project in Key Areas of Guangdong Province [2019B090917011]
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Cardiovascular disease is a leading cause of death, and one of the effective therapeutic strategies for cardiovascular disease is to provide a controlled, constant supply of nitric oxide (NO) in a mild manner; however, this has proved challenging in the clinic. To address this problem, we built a nitric oxide synthase (NOS)-like nanoplatform (NanoNOS) that consists of a noble metal nanoparticle core and a mesoporous silica shell and demonstrated the ability of NanoNOS to catalyze production of NO in vitro. Mechanistic studies show that the catalysis consists of a three-step reaction: the oxidation of NADPH to produce O-2 center dot(-) via oxidase-like activity and the subsequent dismutation of O-2 center dot(-) to H2O2 via SOD -like activity, followed by H2O2-mediated oxidation of L-arginine to produce NO via a nonenzymatic pathway. The generation of NO is precisely regulated by both the content of the NanoNOS species and the plasmon excitation. We found that NanoNOS greatly suppressed injury-driven monocyte-endothelial cell adhesion, suggesting the NanoNOS treatment could help prevent cardiovascular disease. With such a design as well as plasmon excitation that allows Ifor controlled and constant catalytic activity, NanoNOS technology could have a variety of biomedical applications.
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