Journal
ACS NANO
Volume 14, Issue 10, Pages 12708-12718Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c02358
Keywords
inorganic nanoparticles; poly(2-oxazoline); protein corona; protein adsorption; isothermal titration calortmetry; polymer brushes; cyclic polymers
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Funding
- Austrian Science Fund (FWF) [13064]
- EQ-BOKU VIBT GmbH
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Linear and cyclic poly(2-ethyl-2-oxazoline) (PEOXA) adsorbates provide excellent colloidal stability to superparamagnefic iron oxide nanoparticles (FexOy NPs) within protein-rich media. However, dense shells of linear PEOXA brushes cannot, prevent weak but significant attractive interactions with human serum albumin. In contrast, their cyclic PEOXA counterparts quantitatively hinder protein adsorption, as demonstrated by a combination of dynamic light scattering and isothermal titration calorimetry. The cyclic PEOXA brushes generate NP shells that are denser and more compact than their linear counterparts, entirely preventing the formation of a protein corona as well as aggregation, even when the lower critical solution temperature of PEOXA in a physiological buffer is reached.
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