Journal
ACS CHEMICAL NEUROSCIENCE
Volume 11, Issue 17, Pages 2489-2491Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.0c00512
Keywords
SARS-CoV-2; iPSCs; human neural progenitor cell; neurosphere; organoid; brain infection
Funding
- National Natural Science Foundation of China [81671293, 81974502, 81302750]
- Natural Science Foundation of Hunan Province [2020JJ3061]
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Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a severe public health problem with a high rate of morbidity and mortality. A mounting number of clinical investigations illustrate that COVID-19 patients suffer from neurologic conditions in addition to respiratory symptoms. In a recent article, Yuen and colleagues present the first experimental evidence of SARS-CoV-2 infection in the human central nervous system using induced pluripotent stem cells (iPSCs)-derived platform including human neural progenitor cells, neurospheres, and three-dimensional brain organoids (Yuen, K.Y., and Huang, J.D. et al. (2020) Cell Res. DOI: 10.1038/s41422-020-0390-x).
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