Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 41, Pages 46827-46836Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c15729
Keywords
hyaluronic acid; sulfur contents; endothelial cells; smooth muscle cells; macrophages
Funding
- National Natural Science Foundation of China [U1804251]
- National Key Research and Development Program of China [2017YFB0702500, 2018YFC1106703, 2016YFC1102403]
- Top Doctor Program of Zhengzhou University [32210475]
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Hyaluronic acid (HA) is recognized as a functional carbohydrate polymer applied for the surface modification of cardiovascular implanted materials due to its molecular weight (MW) dependent cellular regulation. However, due to the enzyme digestion of hyaluronidase on HA in vivo, the stability of HA MW needs to be further improved. It has been reported that the stability of HA MW can be improved by sulfonation. In this study, sulfonated hyaluronic acids (S-HA) with sulfur content of 2.06, 3.69, 7.10, 8.98, and 9.71 were prepared through different sulfuric acid treatment procedures. Cell tests showed that S-HA with higher sulfur content played a significant role in promoting the proliferation and migration of endothelial cells and regulating smooth muscle cells to the physiological phenotype. In addition, it was also proved to inhibit the inflammatory macrophages adhesion/activation. Our data indicates that S-HA may be a better carbohydrate polymer for potential application of cardiovascular biomaterials.
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