Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 44, Pages 49431-49441Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c15494
Keywords
drug delivery; zeolitic imidazolate framework; montmorillonite; nanoplatform; oral medication
Funding
- National Natural Science Foundation of China [21773206, 21473155, 51873185]
- Natural Science Foundation of Zhejiang Province [LZ12B03001]
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Oral administration of medicine faces physiological constraints imposed by the gastrointestinal tract (GIT) and simultaneously causes irritation to GI mucosa, which motivates us to pursue the innovation of a GI drug delivery system. Inspired by the mucosa-nutrient functions of Zinc element and smectite clay, a montmorillonite (MMT)enveloped zeolitic imidazolate framework (M-ZIF-8) is developed in a successive one-pot fabrication of ZIF-8 encapsulated medicine, and followed MMT coating to yield a core-shell nanoplatform for GI drug delivery. ZIF-8 encapsulated medicines can maintain their intrinsic structure, and MMT layer potentiates mucous-adhesion and optimizes medicine release. Validated in gastritis and colitis models, M-ZIF-8 not only achieves efficient GI delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) for inflammation inhibition, but also reduces the NSAIDs-induced GI irritation, promoting mucosal healing in GIT. Coupled with the facile construction and biocompatibility, M-ZIF-8 shows a significant advancement in GI drug delivery.
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