Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 41, Pages 45673-45701Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c12410
Keywords
functional nanofibers; electrospinning; solution blow spinning; centrifugal spinning; microfluidic spinning; biomedical applications
Funding
- FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) from Brazil [2017/20973-4, 2017/12174-4, 2018/22214-6]
- CNPQ (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) from Brazil
- FAPEMIG (Fundacao de Amparo a Pesquisa de Minas Gerais) from Brazil [APQ-01505-15, APQ00906-17]
- MCTI-SisNano from Brazil [CNPq/402.287/2013-4]
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior) from Brazil [001]
- Rede Agronano-Embrapa from Brazil
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Functional polymeric micro-/nanofibers have emerged as promising materials for the construction of structures potentially useful in biomedical fields. Among all kinds of technologies to produce polymer fibers, spinning methods have gained considerable attention. Herein, we provide a recent review on advances in the design of micro- and nanofibrous platforms via spinning techniques for biomedical applications. Specifically, we emphasize electrospinning, solution blow spinning, centrifugal spinning, and microfluidic spinning approaches. We first introduce the fundamentals of these spinning methods and then highlight the potential biomedical applications of such micro- and nanostructured fibers for drug delivery, tissue engineering, regenerative medicine, disease modeling, and sensing/biosensing. Finally, we outline the current challenges and future perspectives of spinning techniques for the practical applications of polymer fibers in the biomedical field.
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