Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 39, Pages 43456-43465Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c12824
Keywords
covalent organic framework; poly(p-phenylenediamine); phototherapy; chemodynamic therapy; immunotherapy
Funding
- National Natural Science Foundation of China [NSFC 21471145]
- Science and Technology Development Planning Project of Jilin Province [20170101179JC]
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Cancer deaths are mainly caused by tumor metastases. However, tumor ablation therapies can only target the primary tumor but not inhibit tumor metastasis. Herein, a multifunctional covalent organic framework (COF)-based nanocomposite is designed for synergetic photo-, chemodynamic- and immunotherapies. Specifically, the synthesized COF possesses the ability to produce singlet oxygen under the 650 nm laser irradiation. After being metallized with FeCl3, p-phenylenediamine is polymerized on the surface of COF with Fe3+ as the oxidant. The obtained poly(p-phenylenediamine) can be used for photothermal therapy. Meanwhile, the overexpressed H2O2 in the tumor would be further catalyzed and decomposed into hydroxyl radicals ((OH)-O-center dot) by the Fe3+/Fe2+ redox couple via Fenton reaction. Intriguingly, the increase of temperature caused by photothermal therapy can accelerate the production of (OH)-O-center dot. Moreover, the tumor-associated antigen induced a robust antitumor immune response and effectively inhibited tumor metastasis in the presence of anti-PD-L1 checkpoint blockade. Such a COF-based multifunctional nanoplatform provides an efficacious treatment strategy for both the primary tumor and tumor metastasis.
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