Journal
FOOD SCIENCE AND HUMAN WELLNESS
Volume 10, Issue 1, Pages 103-111Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.fshw.2020.04.014
Keywords
Sturgeon; Enzymatic hydrolysis; Antioxidant; Anti-inflammation mechanism; RAW264.7 macrophages
Categories
Funding
- China Agriculture Research System [CARS-46]
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The study investigated the anti-inflammatory potential of sturgeon peptides, finding that they significantly reduce the expression of inflammatory mediators and cytokines while also displaying strong antioxidant effects. The peptides exert their anti-inflammatory influence by inhibiting MAPK and NF-kappa B pathways.
Previous studies have suggested that polypeptides extracted from milk, soybean, fish, eggs, and meat possess potential anti-inflammatory effects. To date, few studies have reported the anti-inflammatory function of sturgeon peptides and their underlying mechanisms are unknown. The current study was therefore to determine the anti-inflammatory potential of sturgeon peptides with lipopolysaccharide (LPS)-induced RAW264.7 inflammatory model. Pepsin hydrolysate (PeH) was purified by ultrafiltration and Sephadex G-15 gel filtration chromatography. PeH significantly reduced the inflammatory mediator (NO) and inflammatory cytokines (IL-6, TNF-alpha. and IL-1 beta) expression in a dose-dependent manner. Moreover, the purified sturgeon peptide (F2) possessed strong antioxidant potential and effectively inhibited DPPH and ABTS free radicals. F2 significantly suppressed the expression of MAPK, I kappa B alpha, and NF-kappa B p65, indicating that F2 exerted anti-inflammatory influence by the inhibition of MAPK and NF-kappa B pathways. (C) 2021 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
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