Journal
ISCIENCE
Volume 23, Issue 7, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.isci.2020.101281
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Categories
Funding
- National Research Programs of China [2016YFA0201200]
- National Natural Science Foundation of China [21574035, 31800834, 51525203, 51761145041, 51572180]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Jiangsu Natural Science Fund for Distinguished Young Scholars [BK20170063]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
- Fundamental Research Funds for the Central Universities [JZ2018HGA0273]
- University Synergy Innovation Program of Anhui Province [GXXT-2019-045]
- [KYCX19_1917]
- [KYCX19_1923]
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Bacterial infections caused by pathogens have always been a thorny issue that threatens human health, and there is urgent need to develop a new generation of antimicrobial nano-agents and treatments. Herein, biodegradable nickel disulfide (ND) nanozymes as excellent antibacterial agents that integrate excellent photothermal performance, nano-catalysis property, and glutathione (GSH)-depleting function have been successfully constructed. The ND nanozymes can effectively catalyze the decomposition of H2O2 to produce,OH, and the hyperthermia of ND nanozymes generated by photothermal therapy (PTT) can further increase its catalytic activity, which provides rapid and effective bacterial killing effect compared with nano-catalytic treatment or PTT alone. Surprisingly, the ND nanozymes have the ability of GSH consumption, thus enhancing its sterilization effect. Moreover, the ND nanozymes are biodegradable nanomaterials that do not cause any significant toxicity in vivo. Collectively, the ND nanozymes with excellent photothermal performance, catalytic activity, and GSH-depleting function are used for high-efficiency sterilization.
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