Journal
BIOMEDICINES
Volume 8, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines8080277
Keywords
ADMA; arginine; arginine paradox; BH4; blood pressure; COVID-19; dietary supplements; endothelial dysfunction; endothelium; eNOS uncoupling; heart failure; hypertension; L-arginine; myocardial infarction; NADPH; nitric oxide; oxidative stress; peripheral artery disease
Categories
Funding
- NIH [R01-DK123259, R01-HL146691, R01-DK033823, R00-DK107895]
- American Heart Association [AHA-20POST35211151]
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Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.
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