4.7 Article

Distribution of Helicobacter pylori and Periodontopathic Bacterial Species in the Oral Cavity

Journal

BIOMEDICINES
Volume 8, Issue 6, Pages -

Publisher

MDPI
DOI: 10.3390/biomedicines8060161

Keywords

Helicobacter pylori; Porphyromonas gingivalis; periodontopathic bacterial species; molecular biological analysis; oral specimens

Funding

  1. JSPS KAKENHI [JP18K17252]

Ask authors/readers for more resources

The oral cavity may serve as a reservoir of Helicobacter pylori. However, the factors required for H. pyloricolonization are unknown. Here, we analyzed the relationship between the presence of H. pylori in the oral cavity and that of major periodontopathic bacterial species. Nested PCR was performed to detect H. pylori and these bacterial species in specimens of saliva, dental plaque, and dental pulp of 39 subjects. H. pylori was detected in seven dental plaque samples (17.9%), two saliva specimens (5.1%), and one dental pulp (2.6%) specimen. The periodontal pockets around the teeth, from which dental plaque specimens were collected, were significantly deeper in H. pylori-positive than H. pylori-negative subjects (p < 0.05). Furthermore,Porphyromonas gingivalis, a major periodontopathic pathogen, was detected at a significantly higher frequency in H. pylori-positive than in H. pylori-negative dental plaque specimens (p < 0.05). The distribution of genes encoding fimbriae (fimA), involved in the periodontal pathogenicity of P. gingivalis, differed between H. pylori-positive and H. pylori-negative subjects. We conclude that H. pylori can be present in the oral cavity along with specific periodontopathic bacterial species, although its interaction with these bacteria is not clear.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available