Combination of chemocatalysis and biocatalysis in flow

With increased efforts towards enzyme engineering and chemocatalysis in milder conditions, the combination of chemocatalysis and biocatalysis has seen a significant rise in interest. Continuous flow methods have also provided advantages to many catalytic processes, which have been increasingly explored by both academics and industry. This review highlights the different approaches for the combination of chemocatalysis and biocatalysis in continuous flow, together with the main advantages and challenges facing the development of this relatively new research area.