Journal
DIAGNOSTICS
Volume 10, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/diagnostics10080563
Keywords
miR-34a; head and neck squamous cell carcinoma; thyroid cancer
Categories
Funding
- Charles University Research Fund [Progres Q39, Progres Q28/LF1(UNCE 204013)]
- Czech Science Foundation [18-03978S]
- Ministry of Health of the Czech Republic [18-08-00229]
- Pirkanmaa Hospital District
- Pirkanmaa Cancer Foundation
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MiR-34a belongs to the class of small non-coding regulatory RNAs and functions as a tumor suppressor. Under physiological conditions, miR-34a has an inhibitory effect on all processes related to cell proliferation by targeting many proto-oncogenes and silencing them on the post-transcriptional level. However, deregulation of miR-34a was shown to play important roles in tumorigenesis and processes associated with cancer progression, such as tumor-associated epithelial-mesenchymal transition, invasion, and metastasis. Moreover, further understanding of miR-34a molecular mechanisms in cancer are indispensable for the development of effective diagnosis and treatments. In this review, we summarized the current knowledge on miR-34a functions in human disease with an emphasis on its regulation and dysregulation, its role in human cancer, specifically head and neck squamous carcinoma and thyroid cancer, and emerging role as a disease diagnostic and prognostic biomarker and the novel therapeutic target in oncology.
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