Journal
ACS OMEGA
Volume 5, Issue 33, Pages 21094-21103Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.0c02744
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Funding
- Government of the Kingdom of Saudi Arabia
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NMR spectroscopy is a powerful technique for separating and measuring each distinct pK(a) value of the amino groups around aminoglycoside antibiotics. Unambiguous assignments were made for each individual amine substituent on 2-deoxystreptamine, tobramycin, kanamycin B, amikacin, sisomicin, and netilmicin using variations in the NMR spectroscopic chemical shift (delta) with H-1, C-13, and N-15 HMBC; the individual pK(a) values of netilmicin are reported for the first time.
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