Journal
ACS OMEGA
Volume 5, Issue 31, Pages 19661-19666Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.0c02339
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Funding
- National Key R&D Program of China [2017YFD0201105]
- National Natural Science Foundation of China [31870331]
- Natural Science Foundation of Shaanxi Province, China [2017JM3015]
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Four new 8-O-4' neolignans, characterized at methoxy or ethoxy groups substituted at C-7, namely, (+/-) lasiandranins A-D (1-4), and two known analogs (+/-) pinnatifidanin BV (5) and (+/-) pinnatifidanin BVI (6) were isolated from the whole plants of Clematis lasiandra Maxim. The structures of 1-6 were determined by spectroscopic methods including 1D, 2D NMR, ECD, and HRESIMS analysis. Compounds 1 and 5 were determined as erythro configuration, while 2-4 and 6 were determined as threo configuration based on the chemical shift difference of H-9a and H-9b in CD3OD. The 8-O-4' neolignans were found from the genus Clematis for the first time. Compounds 1-6 were evaluated for their antibacterial activity against three plant pathogenic bacteria Pseudomonas syringae pv. actinidiae, Ralstonia solanacearum, and Erwinia carotovora by agar and broth dilution methods. Compounds 1-6 showed potent antibacterial activity against R. solanacearum with MIC values of 25-50 mu g/mL and relatively lower activity against P. syringae pv. actinidiae with MIC values of 50-100 mu g/mL, while they were inactive to E. carotovora.
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