Journal
ACS OMEGA
Volume 5, Issue 25, Pages 15631-15656Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.0c01854
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Funding
- Japan Society for the Promotion of Science (JSPS) KAKENHI Grant in Middle Molecular Strategy [JP18H04402, JP17K05860]
- AMED [JP19ak0101091h0002]
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Synthesis of 2,3-disubstituted 4-ethoxycarbonyl-beta-carbolin-1-ones is developed using palladium-catalyzed intramolecular amination of 3-amino-4-(2-bromophenyl)-2-pyridones prepared by the conjugate addition reaction of diethyl 2-aminomalonate to alkynyl imines. The method was applied to the total syntheses of SL651498 exhibiting anxiolytic activity and its analogue.
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