Journal
ENVIRONMENTAL TECHNOLOGY & INNOVATION
Volume 19, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.eti.2020.100838
Keywords
Pharmacokinetic; Pkweb; R shiny; Online application; Prior parameters
Funding
- Major Science and Technology Program for Water Pollution Control and Treatment, China [2018ZX07208001]
- National Natural Science Foundation of China (Youth Program) [21707006]
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This research presents a web-based application, pkweb (https://pkweb.hhra.net), with a user-friendly interface and a range of functions for pharmacokinetic (PK) data analysis. Capabilities include simulation of PK data, which integrates 27 modules (e.g., intravenous (IV) bolus injection, IV infusion and extravascular administration) and modeling the fitness of PK data. The pkweb tool provides different solutions for various conditions, such as compartmental analysis (CA) under single dosing, non-compartmental analysis (NCA) under single dosing and CA under multiple dosing. Compared to other tools, a unique feature of this tool is the ability to set boundaries for the parameters of each model. This newly released application promises to facilitate both toxicokinetic and pharmacokinetic data analysis. (C) 2020 Elsevier B.V. All rights reserved.
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