Journal
ANTIBIOTICS-BASEL
Volume 9, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/antibiotics9060325
Keywords
antibiotic resistance; plant secondary metabolites; plant-derived natural products; terpenes; diterpenes; triterpenes; multidrug-resistant strains
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Funding
- PON (Piano Operativo Nazionale) [ARS01_00432]
- PRIN 2017-Targeting Hedgehog pathway: Virtual screening identification and sustainable synthesis of novel Smo and Gli inhibitors and their pharmacological drug delivery strategies for improved therapeutic effects in tumors by the Italian Ministry of Educ
- Sapienza University of Rome
- MIUR - Dipartimenti di Eccellenza
- Sapienza University of Rome [RM11816436113D8A]
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The discovery of antibiotics has revolutionized the medicine and treatment of microbial infections. However, the current scenario has highlighted the difficulties in marketing new antibiotics and an exponential increase in the appearance of resistant strains. On the other hand, research in the field of drug-discovery has revaluated the potential of natural products as a unique source for new biologically active molecules and scaffolds for the medicinal chemistry. In this review, we first contextualized the worldwide problem of antibiotic resistance and the importance that natural products of plant origin acquire as a source of new lead compounds. We then focused on terpenes and their potential development as antimicrobials, highlighting those studies that showed an activity against conventional antibiotic-resistant strains.
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