Journal
FRONTIERS IN MEDICINE
Volume 7, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2020.00351
Keywords
GRP78; endoplasmic reticulum stress; autophagy; apoptosis; tumor-targeted therapy
Categories
Funding
- National Natural Science Foundation of China [81541153]
- Guangdong Science and Technology Department [2016A050503046, 2015A050502048, 2019B090905011]
- Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang [ZJW-2019-07]
- Public Service Platform of South China Sea for R&D Marine Biomedicine Resources [GDMUK201808]
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The 78-kDa glucose-regulated protein (GRP78) plays an important part in maintaining protein stability, regulating protein folding, and inducing apoptosis autophagy, which is considered as a powerful protein. Meanwhile, it also plays a role in ensuring the normal function of organs. In recent years, more and more researches have been carried out on the targeted therapy of GRP78, mainly focusing on its relevant role in tumor and its role as a major modulator and modulator of subordinate pathways. The ability of GRP78 to respond to endoplasmic reticulum stress (ERS) determines whether tumor cells survive and whether the changes in expression level of GRP78 regulated by endoplasmic reticulum (ER) caused by various factors will directly or indirectly affect cell proliferation, apoptosis, and injury, or reduce the body's defense ability, or have protective effects on various organs.
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